Improve Your Cognitive Abilities with Modafinil 200 mg

Cognition is the process of perceiving, recognizing, conceiving, sensing, reasoning, and imagining. Modafinil Online Australia has been shown to enhance cognitive abilities in healthy, non-sleep-deprived neurotypical volunteers.

However, it was found that modafinil did not improve performance on a typical hippocampal memory test or delayed visual recognition task and did not increase the learning of motivational reinforcement tasks.

Improved Concentration

If you find yourself struggling with concentration, there are several things you can do to improve your focus. Getting enough sleep, staying away from caffeine and other stimulants, taking up brain training exercises, and improving your diet can all help. However, if you still struggle with poor concentration, speak to your doctor about possible underlying health conditions that may be contributing to your issues.

Modafinil has shown efficacy in several neurological and psychiatric illnesses currently treated with amphetamine, with improved side-effect profiles including a low liability for abuse (see comprehensive review of these studies in Ballon and Feifel, 2006).

It is also known to improve cognitive function, particularly working memory and episodic memories, and to enhance processes requiring mental control (e.g. attentional set shifting), in both human subjects and animal models, reflecting effects mediated by fronto-cortical DA systems.

In a single-dose study of adults with 85 h of sleep deprivation, Modalert 200 mg reduced errors in the Wisconsin Card Sort Test and interference in the Stroop task, compared to placebo.

These effects were comparable to those observed in another study comparing modafinil with 600 mg of caffeine and 20 mg of amphetamine. Similarly, the onset of modafinil’s wake-promoting effect in medication-free narcoleptic patients was associated with a reduction in errors in the Pauli Test.

Improved Memory

Modafinil appears to enhance cognitive abilities in non-sleep-deprived subjects, notably working memory, and processes requiring cognitive control. These improvements are thought to be mediated by the pharmacological action of modafinil on central catecholaminergic systems. In addition, modafinil has a less extensive side-effect profile than amphetamine and a lower liability for abuse.

For example, one study using a double-blind design found that a single dose of modafinil improved performance on digit span and an attention task involving alternating between two colors (Wilson et al, 2004). In other studies, add-on modafinil treatment enhanced cognitive performance in schizophrenia patients during a 20-h observation period measured by wrist-worn actigraphy (Czeisler et al, 2005; Hart et al, 2006).

Modafinil also improves working memory in animal models. Pre-treatment with modafinil leads to a dose-dependent increase in alternation rates on a sequential alternation task in mice, without affecting exploratory or anxiety-related activity. Changes in behavioral performance were correlated with changes in left BA 46 activity in the same study.

In human studies, modafinil has been shown to improve digit span, visual recognition memory, spatial planning, and SSRT tasks in healthy non-sleep-deprived volunteers (Randall et al, 2005b). A similar study with military recruits following 64 hours of continuous work found that modafinil and methylphenidate both improved accuracy on the CPT test, indicating a benefit for executive function under fatigue.

Improved Attention

Several studies have demonstrated the efficacy of modafinil on various aspects of cognition in human subjects. In one study, a single dose of modafinil significantly improved performance on digit span (forward and backward) and delayed visual recognition memory tests in adults with ADHD as compared to placebo.

This effect was associated with slowed latencies and increased accuracy on these measures, and with corresponding increases in left frontal BA 46 activity. This finding suggests that modafinil improves the ability to shift attention to a task-relevant stimulus, an ability that may be mediated by ascending dopamine systems.

A similar effect was observed in a double-blind, placebo-controlled trial of sleep-deprived emergency physicians who were given either modafinil 200 mg or d-amphetamine 20 mg after an overnight work shift. Modafinil improved performance on a digit span test and a visual sustained attention task, but did not affect omission errors in the PAL test, or on measures of motivation or motor activity.

Interestingly, this group has also found that single-dose modafinil improves performance on a digit span test in college students with high IQs, indicating that the cognitive improvements seen in other studies are likely to be due to ceiling effects.

Modafinil has been shown to enhance episodic memory function in remitted depressed patients by improving the rate of spontaneous alternation on a sequential alternation task, without affecting exploratory or anxiety-related behavior (Beracochea et al 2001). This improvement could be mediated by changes in glutamate signaling to the hippocampus, as modafinil has been shown to increase hippocampal levels of glutamine synthetase in animals.

Improved Focus

Modafinil is well known for its wakefulness-enhancing effects in sleep-deprived people, but studies have found that it also enhances cognitive performance in healthy, non-sleep-deprived individuals. Specifically, it appears to improve executive functions (e.g., planning and organizing) and improve memory.

Various studies have shown that it improves performance on tests measuring attention, learning, and memory, including the WCST, Hayling sentence completion task, and a version of the digit symbol test. However, in one study, modafinil was associated with impaired divergent creative thinking, which is an important aspect of cognitive flexibility.

It has been found that, like caffeine, modafinil improves objective alertness on a variety of tasks and increases the speed of response on some. In addition, unlike caffeine, it does not impair the ability to return to sleep after awakening. The maximum daily dose of modafinil is 400 mg in divided doses, but this can be increased depending on the physician’s assessment of the patient and his or her response.

In a double-blind placebo-controlled study, modafinil improved errors on the WCST and a prefrontal-dependent measure of cognitive control, the Stroop interference task. The participants in the study were matched on age, gender, premorbid IQ, depressive symptom scores, and anxiety levels.

After a baseline session, the participants received either modafinil or a placebo. They then completed a series of assessments including the Fatigue Severity Scale, visual analog scales, and anxiety ratings.


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